The objectives of this research were 1) to study Isan identity. A case study of Khon Kaen 2) to design graphics from Isan identity, a case study of Khon Kaen Province; 3) to design a user manual of graphics from Isan identity, a case study of Khon Kaen Province. The initial variable was defined as a graphic manual from Isan identity. Case study: Khon Kaen Province. The dependent variable was the quality of a graphic manual from Isan identity, a case study: Khon Kaen Province. and user satisfaction and from conducting a study on Isan identity within Khon Kaen. It was found that the stories, lifestyles and cultures were introduced. tradition And the surrounding nature of the local area is used to create an identity in the industry. There are quite a lot of local handicrafts. And there are also local identities that have recently been discovered, such as ancient paintings at Phu Wiang National Park and Nam Phong National Park. From the design of the Isan graphic manual, a case study of Khon Kaen Province. It was found that the design of the manual that emerged from the study of graphics from the Isan identity in Khon Kaen Efficiency = 4.67 and S.D. = 0.43, which is of very good quality. And the satisfaction of the users with the value = 4.45 and S.D. = 0.44 had a very good level of satisfaction. Therefore, the Isan Graphic Handbook, Case Study of Khon Kaen Province, is suitable to be used as a guideline for use in creating and designing appropriately for organizations and businesses in the Khon Kaen area.